Malmö haven't earned a Europa League win this season, and have the chance to earn a shock result on the road against Porto.
Match Replays
Viktoria Plzeň are unbeaten after five Europa League matches and take on a Panathinaikos side who are coming off two straight wins.
Go Ahead Eagles are looking for a shock result when they travel to take on Lyon, who sit at the top of the UEFA Europa League table.
RB Salzburg are looking to get back in the win column when they travel to Freiburg to take on the unbeaten German side.
FCSB have lost four straight but have the chance to bounce back when they host a Feyenoord side that sits tied on three points.
Celtic earned a win last time out and play host to a surging Roma side that have won two straight in the UEFA Europa League.
Celta dropped a three-match losing streak and now play host to Bologna, who are unbeaten in their last four matches.
Brann are unbeaten in their last four Europa League matches before they play host to a Fenerbahçe, who are similarly unbeaten in four.
Aston Villa look to continue their brilliant Europa League form when they take on Basel, who have alternated wins and losses through five matches.
Lille snapped a two-match skid last time out and now have the chance to extend that when they take on Young Boys in Switzerland.
Nottingham Forest are unbeaten in their last three ahead of a trip to Utrecht, who are still looking for their first Europa League win.
Maccabi Tel-Aviv have lost four in a row ahead of a tough trip to Stuttgart on Matchday 6 in the UEFA Europa League.